T cell metabolism drives immunity

T cell metabolism drives immunity

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal development, during which they undergo a dramatic metabolic remodeling process. Research in this area has yielded surprising findings on the roles of diverse metabolic pathways and metabolites, which have been found to regulate lymphocyte signaling and influence differentiation, function and fate. In this ...

MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity.

BACKGROUND Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and are important regulators of immuno-inflammatory diseases. However, their role in atherosclerosis remains elusive. METHODS AND RESULTS Here, we used genetic approaches to investigate the role of pDCs in atherosclerosis. Selective pDC deficiency in vivo was achieved using CD11c-Cre × Tcf4(-/flox) bone...

Analysis of T - Cell Immunity

1. Abstract 2. Introduction 3. Validating assays for use as surrogate to protective or therapeutic immunity 4. Laboratory issues in improving accuracy and precision 5. Common immunologic monitoring techniques 5.1. T cell proliferation 5.2. Cytolytic T cell assay 5.3. Enzyme linked immunosorbent spot (ELIspot) assay 5.4. Cytokine flow cytometry 5.5. Tetramers 6. Emerging techniques and concepts ...

Purinergic P2X7 Receptor Drives T Cell

Dendritic cell metabolism: immunity and tolerance.