منابع مشابه
Systems biology of embryonic morphogens.
A network of secreted proteins that interact with each other in the extracellular space regulates embryonic morphogenesis. Mathematical modeling offers an excellent opportunity to understand how morphogens signal and self-regenerate pattern.
متن کاملEmbryonic pattern formation without morphogens.
One of the earliest and most-fundamental pattern- formation events in embryonic development is endoderm and mesoderm specification. In sea urchin embryos, this process begins with blimp1 and wnt8 gene expression at the vegetal pole as soon as embryonic transcription begins. Shortly afterwards, wnt8/blimp1 expression spreads to the adjacent ring of mesoderm progenitor cells and is extinguished i...
متن کاملInhibitory morphogens and monopodial branching of the embryonic chicken lung.
BACKGROUND Branching morphogenesis generates a diverse array of epithelial patterns, including dichotomous and monopodial geometries. Dichotomous branching can be instructed by concentration gradients of epithelial-derived inhibitory morphogens, including transforming growth factor-β (TGFβ), which is responsible for ramification of the pubertal mammary gland. Here, we investigated the role of a...
متن کاملMorphogens
Hands have five fingers, with each finger different and arranged in a particular order. Obvious perhaps, but the way that this arrangement is achieved during development has intrigued developmental biologists for decades. How do the cells of the hand know whether to form a thumb, index or little finger? More generally, how do cells know where they are within a tissue so that they form the appro...
متن کاملNodal morphogens.
Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postul...
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ژورنال
عنوان ژورنال: Molecular BioSystems
سال: 2007
ISSN: 1742-206X,1742-2051
DOI: 10.1039/b701571b