Systems Biology--Biomedical Modeling

Network modeling in systems biology

...........................................................................................................iv CHAPTER 1. INTRODUCTION ................................................................................... 1 1.1 Background ......................................................................................................... 1 1.2 Network Diagram...................................

Stochastic Modeling in Systems Biology

Many cellular behaviors are regulated by gene regulation networks, kinetics of which is one of the main subjects in the study of systems biology. Because of the low number molecules in these reacting systems, stochastic effects are significant. In recent years, stochasticity in modeling the kinetics of gene regulation networks have been drawing the attention of many researchers. This paper is a...

Hybrid Systems Modeling for (Cancer) Systems Biology

The advent of biological data of increasingly higher resolution in space and time has triggered the use of dynamic models to explain and predict the evolution of biological systems over space and time. Computer-aided system modeling and analysis in biology has led to many new discoveries and explanations that would otherwise be intractable to articulate without the available data and computing ...

Modeling and Simulation of Biomedical Systems

Mechanism-based modeling of complex biomedical systems.

Mechanism-based modeling is an approach in which the physiological, pathological and pharmacological processes of relevance to a given problem are represented as directly as possible. This approach allows us (i) to test whether assumed hypotheses are consistent with observed behaviour, (ii) to examine the sensitivity of a system to parameter variation, (iii) to learn about processes not directl...