Systemic tolerance and secretory immunity after oral immunization.

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Systemic tolerance and secretory immunity after oral immunization

Diminished systemic immune reaction after ingestion of antigen has been reported in several animal models. Conversely, it has been reported recently that oral immunization may lead to the production of secretory antibodies. To determine whether these events could occur concurrently, CBA/J mice were immunized intragastrically with varying doses of ovalbumin (OVA) and Streptococcus mutans. After ...

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Immunologic Tolerance after Specific Immunization

Specific immunologic tolerance to bovine serum albumin (BSA) was induced in approximately one-half of the rabbits that had been primarily immunized and were prepared for a secondary antibody response to BSA. The state of tolerance lasted for several months in the majority of rabbits and was not easily terminated by immunization with human serum albumin followed by BSA.

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Oral immunization with size-purified microsphere beads as a vehicle selectively induces systemic tolerance and sensitization.

Oral administration of antigens has long been recognized as a method to prevent or delay the onset of diseases associated with untoward immune responses to self and non-self antigens. Although oral administration of antigens offers a convenient way to induce systemic tolerance, its therapeutic potential has been seriously limited by the fact that it requires repeated feeding of a large amount o...

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Cell-mediated Immunity and Antibody Responses in the Respiratory Tract after Local and Systemic Immunization

The cell-mediated immune response on the secretory surface of the lower respiratory tract was investigated and compared to the systemic cell-mediated immune response and to the secretory and systemic antibody responses. Guinea pigs were immunized either parenterally or locally with dinitrophenylated human IgG. The effect of rendering animals tolerant on the local cell-mediated response and on t...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1980

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.152.6.1459