Systemic chemotherapy of advanced soft tissue sarcomas
نویسندگان
چکیده
منابع مشابه
Systemic Therapy for Advanced Soft Tissue Sarcomas
Soft tissue sarcomas (STS) are a rare, heterogeneous group of solid tumors in need of improved therapeutic options. First-line chemotherapy is considered the current standard of care for patients with advanced, symptomatic STS, but the median survival is only 8 to 12 months. Efforts to increase response rates by using combination or dose-dense regimens have largely failed to improve patient out...
متن کاملProgress in the Systemic Treatment of Advanced Soft-Tissue Sarcomas.
BACKGROUND: Despite the plethora of chemotherapeutic remedies for advanced soft-tissue sarcomas, little evidence has developed to indicate that these efforts have been curative. No controlled comparison has yet proven that patients receiving multidrug regimens survive longer than those receiving doxorubicin alone. METHODS: The authors review current systemic treatments and then discuss some inv...
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BACKGROUND Soft tissue sarcomas (STS) are a heterogeneous group of tumors, and approximately 40-50% of patients with STS develop metastatic disease. The median overall survival of those patients was 12 months and their 5-year survival rate was 8%. Therefore, study on more effective treatment, especially the targeting therapies, is urgently needed. OBJECTIVE To evaluate the efficacy and safety...
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Background: Evaluating the potential role of standardized uptake value (SUV) in patients with locally advanced, non-metastased, high-grade, extremity soft tissue sarcoma. Methods: Thirteen patients scheduled for hyperthermic isolated limb perfusion (ILP), referred for a 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)-scan were eligible. The SUV in the sarcoma lesion was calculat...
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Together with surgery and radiotherapy, systemic treatment with cytotoxic chemotherapy and molecular targeted agents is one of the main therapeutic pillars in the treatment of soft-tissue sarcomas and is the mainstay of treatment in patients with advanced or metastatic disease. Unlike other more common malignancies such as breast and colorectal cancer, the role of chemotherapy when used in the ...
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ژورنال
عنوان ژورنال: Journal of Oncological Sciences
سال: 2017
ISSN: 2452-3364
DOI: 10.1016/j.jons.2017.05.001