Systemic and central nervous system metabolome changes associated with Ginkgo biloba treatment in non‐demented subjects

Background In order to characterize the biochemical changes associated with Ginkgo biloba treatment, at metabolite and pathway level, we used a state-of-the-art untargeted metabolomics approach in well characterized cohort of healthy non-demented subjects, or without treatment. Method We analysed data including cerebrospinal fluid (CSF) peripheral blood measurements proteomics, metabolomics, methionine pathway, lipidomics, minerals, miRNAs, sterols neuroinflammatory markers samples obtained from both groups, covering over 2500 analytes and/or molecules. Result Data analysis individual metabolic levels revealed differences expression 15 CSF level 25 blood, 13 unidentified miRNAs. Pathway enrichment these were an overrepresentation insulin signalling, platelet degranulation hemostasis growth factor signalling levels. Conclusion These results demonstrate ability this uncover patients undergoing further steps, will perform build multivariate models accounting for potential confounders multi-omics model, assess interactions between different biological pathways levels; approaches require recruitment additional participants gingko group. This also allow targeted omics explore alterations relate them clinical evolution time, cognitive decline non-cognitive symptoms follow-up visits.