Systematic synergy modeling: understanding drug synergy from a systems biology perspective
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چکیده
منابع مشابه
Understanding synergy.
Analysis of the interactive effects of combinations of hormones or other manipulations with qualitatively similar individual effects is an important topic in basic and clinical endocrinology as well as other branches of basic and clinical research related to integrative physiology. Functional, as opposed to mechanistic, analyses of interactions rely on the concept of synergy, which can be defin...
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CC-BY 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Abstract 1 Although drug combinations have proven efficacious in a variety of diseases, the design of such 2 regimens often involves extensive experimental screening due to the myriad choice of drugs and 3 doses. To address these challenges, we...
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The term synergy is derived from the Greek syn-ergos, "working together". Synergies have been described in many settings and situations of life, including mechanics, technical systems, human social life, and many more. In all cases, synergy describes the fact that a system, i.e. the combination and interaction of two or more agents or forces is such that the combined effect is greater than the ...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2015
ISSN: 1752-0509
DOI: 10.1186/s12918-015-0202-y