Systematic identification of functional SNPs interrupting 3’UTR polyadenylation signals
نویسندگان
چکیده
منابع مشابه
Human microRNA Polyadenylation Signals
MicroRNAs (miRNAs) are small non-coding RNAs that are involved in posttranscriptional gene regulation (cf., Bartel, 2004). First identified in C. elegans just over a decade ago (Lee et al., 1993), miRNAs have been identified in virtually every metazoan and plant species examined. Experimental evidence is rapidly accumulating that shows miRNAs to play key roles in process such as cellular differ...
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Analysis of 37 short repetitive elements (SINEs) in rabbit DNA that are known as C repeats has revealed three that contribute functional polyadenylation signals to genes into which they have been inserted. Similar roles have been attributed to particular individual SINEs in rodents and primates before, suggesting that these roles may be common to SINEs in all mammalian orders. Although most SIN...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2020
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1008977