Synthetic Inhibitors of Proline-Rich Ligand-Mediated Protein-Protein Interaction
نویسندگان
چکیده
منابع مشابه
A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Small-molecule competitors of protein-protein interactions are urgently needed for functional analysis of large-scale genomics and proteomics data. Particularly abundant, yet so far undruggable, targets include domains specialized in recognizing proline-rich segments, including Src-homology 3 (SH3), WW, GYF, and Drosophila enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) homology 1 (E...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2003
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(03)00101-7