Synthetic consortium of Ganoderma lucidum and Lactobacillus plantarum for enhanced natural products biosynthesis

Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products.

Malonyl-CoA is the building block for fatty acid biosynthesis and also a precursor to various pharmaceutically and industrially valuable molecules, such as polyketides and biopolymers. However, intracellular malonyl-CoA is usually maintained at low levels, which poses great challenges to efficient microbial production of malonyl-CoA derived molecules. Inactivation of the malonyl-CoA consumption...

Ganoderma lucidum

The immuno-modulation of Ganoderma lucidum on Natural killer cells

Ganoderma lucidum(G. lucidum) is a medicinal fungus showing a variety of biological functional activities, and has being used as a folk remedy for promotion of health and longevity. One of the most attractive characters of G. lucidum is its diverse immune-modulatory activity, with both activation and inhibition of innate immunne activities identified. These phenomena suggested G. lucidum may co...

Molecular identification of Ganoderma lucidum from Iran

Medicinal mushroom Ganoderma lucidum has been used in East Asia for centuries in order to prevent and treat a variety of diseases such as hepatitis, immunological disorders and cancers. In fact, this fungus contains a vast source of polysaccharides, proteins and secondary metabolites with anti-tumor and immuno-modulatory properties. Up to now, a variety of drug metabolites extracted from G. luc...

Ganoderma lucidum (Reishi mushroom) for cancer treatment.

BACKGROUND Ganoderma lucidum is a natural medicine that is widely used and recommended by Asian physicians and naturopaths for its supporting effects on immune system. Laboratory research and a handful of preclinical trials have suggested that G. lucidum carries promising anticancer and immunomodulatory properties. The popularity of taking G. lucidum as an alternative medicine has been increasi...