Synthetic aminopyrrolic receptors have apoptosis inducing activity

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Synthetic aminopyrrolic receptors have apoptosis inducing activity.

We report two synthetic aminopyrrolic compounds that induce apoptotic cell death. These compounds have been previously shown to act as receptors for mannosides. The extent of receptor-induced cell death is greater in cells expressing a high level of high-mannose oligosaccharides than in cells producing lower levels of high-mannose glycans. The ability of synthetic receptors to induce cell death...

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Synthetic aminopyrrolic receptors have apoptosis inducing activity† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03200h Click here for additional data file.

Center for Biofunctional Molecules, Depa 03722 Seoul, Korea. E-mail: injae@yonsei.a College of Pharmacy, Yonsei Institute of Ph 21983 Incheon, Korea Department of Chemistry, The University Texas, USA Department of Chemistry and INSTM, U Tecnologico, 50019 Sesto Fiorentino, Firenz Istituto di Metodologie Chimiche (IMC), C Department of Chemistry and INSTM, Un Tecnologico, 50019 Sesto Fiorentino,...

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ژورنال

عنوان ژورنال: Chemical Science

سال: 2015

ISSN: 2041-6520,2041-6539

DOI: 10.1039/c5sc03200h