Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity
نویسندگان
چکیده
منابع مشابه
Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies
To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...
متن کاملNovel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies
To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...
متن کاملnovel thiazolidinone-azole hybrids: design, synthesis and antimycobacterial activity studies
to develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to knoevenage...
متن کاملAntimycobacterial pyrroles: synthesis, anti-Mycobacterium tuberculosis activity and QSAR studies.
A number of known antifungal pyrrole derivatives and some newly synthesized compounds (5-33) were tested in vitro against Mycobacterium tuberculosis CIP 103471. The majority of tested compounds were efficient antimycobacterial agents showing MIC values ranging from 0.5 to 32 microg/mL. A 3-D-QSAR study has been performed on these pyrrole derivatives to correlate their chemical structures with t...
متن کاملSynthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplate alamar blu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Infectious Diseases
سال: 2020
ISSN: 2373-8227,2373-8227
DOI: 10.1021/acsinfecdis.0c00252