Synthesis, spectral characterization and biological activities of Ag(I), Pt(IV) and Au(III) complexes with novel azo dye ligand (N, N, O) derived from 2-amino-6-methoxy benzothiazole

The novel ligand 2-[2'-(6-methoxybenzothiazolyl)azo]-3,5-dimethyl benzoic acid (6-MBTAMB), derived from 2-amino-6-methoxy benzothiazole, has been used to synthesize a series of new metal complexes Ag(I), Pt(IV) and Au(III). were characterized by elemental analyses (CHNS), molar conductivity, crystal structure (XRD), spectroscopic techniques: FT-IR, 1H NMR, 13C UV–Vis, mass spectra, thermal analysis (TG–DTA), FE-SEM magnetic properties. Results confirmed that the azo dye behaves tridentate coordinates ion via nitrogen atom azomethine group heterocyclic benzothiazole ring, which is farthest molecule carboxylic oxygen. Antimicrobial properties all newly synthesized compounds are also demonstrated against bacterial pathogenic organisms fungi. These more effective bacteria less fungi compared standard antibacterial drugs (novobiocin) antifungal (cycloheximide). By using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging test, it was discovered had good antioxidant In addition, (6-MBTAMB) docked with FGF Receptor 2 (FGFR2) kinase domain harboring gain function K659E mutation identified in endometrial cancer molecular operating environment (MOE) module. vitro studies on human cell lines (MFE-296) as well healthy umbilical vein endothelial cells (HUVEC) show uptake intact increased activity cells.Graphical abstract