Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors
نویسندگان
چکیده
منابع مشابه
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors.
Phenols are among the largest and most widely distributed groups of secondary metabolites within the plant kingdom. They are implicated in multiple and essential physiological functions. In humans they play an important role as microconstituents of the daily diet, their consumption being considered healthy. The physical and chemical properties of phenolic compounds make these molecules versatil...
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Carbonic anhydrase (CA) inhibitors are valuable molecules based on several therapeutic applications, including antiglaucoma activity. In the present study, inhibition of two human cytosolic carbonic anhydrase isozymes I and II with some uracil derivatives (3-9) were investigated. Compounds 3-9 showed KI values in the range of 10.83-464 μM for hCA I and of 28.88-778.5 μM against hCA II, respecti...
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Carbonic anhydrase (CA) inhibitors are very interesting target for designing anticancer (hypoxic) and antiglaucoma drugs. In the present study, a 3D homology modeling of human carbonic anhydrase-IX (hCA-IX) isozyme, based upon the crystal structure of murine CA-XIVA (PDB CODE 1RJ5) was performed, as no experimental 3D structures are available. A homology model of hCA-IX was developed and valida...
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1Department of Pharmaceutical Sciences and Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad, Pakistan 2Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, Pakistan 3Division of Biophysics, Department of Basic Medical Sciences, School of Medicine, Bahçeşehir University, Turkey 4Institute of Biostructu...
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The zinc enzymes carbonic anhydrases (CAs, EC 4.2.1.1) are very efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate and hence play an important physiological role. In humans, 16 different isozymes have been described, some of them being involved in various pathological disorders. Several of these isozymes are considered as drug targets, and the design of selective ...
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ژورنال
عنوان ژورنال: Organic Communications
سال: 2017
ISSN: 1307-6175
DOI: 10.25135/acg.oc.4.16.05.418