SYNTHESIS OF p-AMINOHIPPURIC ACID BY MITOCHONDRIA OF MOUSE LIVER HOMOGENATES
نویسندگان
چکیده
منابع مشابه
Synthesis of p-aminohippuric acid by mitochondria of mouse liver homogenates.
In studies on the enzyme system in rat liver which synthesizes p-aminohippuric acid (PAH) from p-aminobenzoic acid (PAB) and glycine, Cohen and McGilvery (1) found most of the enzyme activity in the washed residue of the homogenate. Since their preparation contained all the nuclei and part of the mitochondria of the homogenate, the relative activities of the individual intracellular components ...
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The capacity of cell-free preparations of neo plastic tissue to carry out synthetic reactions has not been widely investigated. The desirability of such studies is apparent, since information might be provided which would bear on the integrated metabolic functions of the cell, particularly in re lation to the coupling of oxidative energy with the synthetic reactions. Previous studies in this la...
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Synthesis of p-aminohippuric acid (PAH) from p-aminobenzoic acid (PAB) in animal liver slices and homogenates has been shown to resemble closely, both chemically and thermodynamically, the synthesis of peptides (1-3). This reaction has been utilized in the hippuric acid synthesis test for liver function since 1933 (4) and has found wide clinical application (5-7). Hippuric acid, however, must b...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1950
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56378-x