Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors
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چکیده
منابع مشابه
Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors
In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, and N,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a-5f) showed the most potent mushroom tyrosinase inhibition (IC₅₀ values in the range of 4.39 ± 0.76-1.71 ± 0.49 µM), compara...
متن کاملIsoprenylated Phenolic Compounds from Morus macroura as Potent Tyrosinase Inhibitors.
Three new Diels-Alder adducts, macrourins E - G (1: -3: ), one new 2-arylbenzofuran, macrourin H (4: ), and eight known Diels-Alder adducts (5: -12: ) were isolated from Morus macroura. Their structures were elucidated through extensive analysis of spectroscopic data. The 1H NMR and ECD trends in the determination of the configurations of these Diels-Alder adducts were summarized. The tyrosinas...
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Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...
متن کاملConventional Organic Solvents and Ionic Liquid Mediated Synthesis of New Azomethine Compounds as Potent Cholinesterase Inhibitors Basma M. Abd Razik Universiti Sains Malaysia 2016 Conventional Organic Solvents and Ionic Liquid Mediated Synthesis of New Azomethine Compounds as Potent Cholinesterase Inhibitors
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2013
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2013/207181