منابع مشابه
Synthesis of leukotriene B3 derivatives.
Leukotriene B4(LTB4), a metabolite of arachidonic acid, has been reported to have various pharmacological actions such as chemotaxis, chemokinesis, aggregation and degranulation of leukocytes in vitro.' Therefore, it is thought to be a primary mediator in inflammatory and allergic states, and inhibitors of its actions are expected to have therapeutic potential. We planned to synthesize several ...
متن کاملAmiloride derivatives inhibit coxsackievirus B3 RNA replication.
Amiloride derivatives are known blockers of the cellular Na(+)/H(+) exchanger and the epithelial Na(+) channel. More recent studies demonstrate that they also inhibit ion channels formed by a number of viral proteins. We previously reported that 5-(N-ethyl-N-isopropyl)amiloride (EIPA) modestly inhibits intracellular replication and, to a larger extent, release of human rhinovirus 2 (HRV2) (E. V...
متن کاملLeukotriene synthesis by epithelial cells.
Leukotrienes (LTs) are intercellular signaling molecules that evoke a variety of responses. They are best known as potent promoters of inflammation. Normally, LTs are produced primarily by leukocytes. As a result, current models regarding the production of LTs in the context of disease focus on the leukocytes as the site of production. Structural cells, including epithelial cells, are typically...
متن کاملMurine Glomerular Leukotriene B4 Synthesis
Leukotriene (LT) B4 is an important pro-inflammatory autocoid. In order to investigate the potential role of this eicosanoid in renal inflammation, in this study we determined the capability of glomeruli to synthesize this mediator. Glomeruli were able to synthesize LTB4 when provided with exogenous substrate in a dose-dependent fashion in the presence of ionophore A23187. Ionophore, although b...
متن کاملOrganization of leukotriene and prostaglandin synthesis
and prostaglandin synthesis As described in the introduction to this Perspective series (1), signaling by arachidonic acid represents a paradigm for the use of oxygen in the transmission of information. At the same time, arachidonic acid signaling can also contribute to the propagation of cellular damage. This duality is typified by a signaling cascade that (a) prevents the activation of 5-lipo...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1987
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.35.2635