منابع مشابه
The synthesis of glycyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycine and its melanocyte-stimulating activity.
Recent work (l-3) on the synthesis of peptides composed of amino acid sequences that appear in both the adrenocorticotropins and the melanotropins has revealed that melanocyte-stimulating activity is enhanced as the length of the peptide chain increases (4). It was shown that the hexapeptide n-glutamyl-nhistidyl-~-phenylalanyl-~-arginyl-~-tryptophyl-glycine possesses an activity almost 10 times...
متن کاملL-arginine recognition by yeast arginyl-tRNA synthetase.
The crystal structure of arginyl-tRNA synthetase (ArgRS) from Saccharomyces cerevisiae, a class I aminoacyl-tRNA synthetase (aaRS), with L-arginine bound to the active site has been solved at 2.75 A resolution and refined to a crystallographic R-factor of 19.7%. ArgRS is composed predominantly of alpha-helices and can be divided into five domains, including the class I-specific active site. The...
متن کاملSynthesis and biological activity of dipeptides containing S-hexylcysteine.
Pathological clot formation is the major cause of many serious diseases. A crucial step at the end of the coagulation cascade is the cleavage of soluble fibrinogen to fibrin clot by thrombin. A number of anticoagulants have been assessed clinically. Side effects such as excessive bleeding and difficulties of drug monitoring have led to considerable activity in the search of novel compounds with...
متن کاملInflux of two dipeptides, glycylsarcosine and L-glutamyl-L-glutamic acid, into hamster jejunum in vitro.
1. This paper reports an investigation of whether the dipeptides glycylsarcosine and L-glutamyl-Lglutamic acid share a single mediated transport mechanism into hamster jejunum, or whether one of these peptides is transported in part by a transport mechanism unavailable to the other. It describes the kinetics of influx of glycylsarcosine and of L-glutamyl-L-glutamic acid into rings of everted ha...
متن کاملIntestinal Transport of Dipeptides
A 30 cm segment of the duodenum, jejunum, or ileum of normal human volunteers was perfused, on separate occasions, with test solutions containing either glycylglycine, free glycine, glycylleucine, or equimolar amounts of free glycine and free leucine. Luminal fluid contained no hydrolytic activity against glycylglycine and minimal activity against glycylleucine. In each intestinal segment, amin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nippon kagaku zassi
سال: 1957
ISSN: 0369-5387,2185-0917
DOI: 10.1246/nikkashi1948.78.1768