Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives

Effect of Purine Nucleoside Analogue-Acyclovir on The Sperm Parameters and Testosterone Production in Rats

Synthesis and Biological Evaluation of 4-hydroxychromenyl arylmethyl-6-hydroxy pyrimidine-2, 4-dione Derivatives

Background: An efficient, promoted tri-component catalytic reaction between barbituric acid (or N,N-dimethyl barbituric acid), 4-hydroxy coumarin, and a wide range of aryl aldehydes using zinc oxide nanowires (ZnO NWs) to obtain some new 4-hydroxychromenylarylmethyl-6-hydroxypyrimidine-2,4-diones is described. Method: The reactants were successfully condensed ...

Nucleotide analogue inhibitors of purine nucleoside phosphorylase.

The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major factor contributing to the superior inhibition by this diphosphate over the corresponding mono- and triphosphates is revealed here. Homologues of ...

Pyrimidine Derivatives and Purine Bases in Soils

In earlier papers the presence of protein decomposition products in soils was reported and it was shown that in soils the changes occurring in the decay of such plant and animal materials as get into the soil are similar to the changes occuring under other conditions in the laboratory or in nature. The presence of arginine and histidine in soils was definitely established by isolating these deg...

The hydrolysis of purine and pyrimidine nucleoside triphosphates by myosin.

It is well established that myosin will catalyze the hydrolysis of inosine triphosphate’ (l-3) as well as ATP. Even catalysis of inorganic triphosphate hydrolysis has been observed (4, 5).2 It has been reported recently (7) that uridine triphosphate is rapidly hydrolyzed in the presence of crystalline myosin, and previously unpublished experiments3 showed that synthetically made UTP4 is rapidly...