Synthesis of Coagulation Factor Xa Inhibitor Apixaban
نویسندگان
چکیده
منابع مشابه
Effects of the oral, direct factor Xa inhibitor apixaban on routine coagulation assays and anti-FXa assays.
INTRODUCTION Apixaban is an oral direct factor Xa inhibitor developed for the prophylaxis and treatment of thromboembolic disorders. Laboratory monitoring is not necessary, but the effects on common coagulation reagents and assays constitute clinically valuable information. OBJECTIVES To investigate the effects of apixaban on commonly used coagulation methods, and to evaluate anti-FXa assays ...
متن کاملEffect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor
BACKGROUND Apixaban is an oral, selective, direct factor Xa inhibitor approved for thromboprophylaxis after orthopedic surgery and stroke prevention in patients with atrial fibrillation, and under development for treatment of venous thromboembolism. This study investigated the effect of a gastric acid suppressant, famotidine (a histamine H2-receptor antagonist), on the pharmacokinetics of apixa...
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Human hookworm infection is a major cause of gastrointestinal blood loss and iron deficiency anemia, affecting up to one billion people in the developing world. These soil-transmitted helminths cause blood loss during attachment to the intestinal mucosa by lacerating capillaries and ingesting extravasated blood. We have isolated the major anticoagulant used by adult worms to facilitate feeding ...
متن کاملEffects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays.
INTRODUCTION Rivaroxaban is an oral direct factor Xa inhibitor developed for prophylaxis and treatment of thromboembolic disorders. Laboratory monitoring is not necessary but the dose-dependent effects on common reagents and assay procedures are largely unknown. OBJECTIVES To investigate the effect of rivaroxaban on commonly used coagulation assays. MATERIALS AND METHODS Rivaroxaban was add...
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Edoxaban: an investigational factor Xa inhibitor.
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ژورنال
عنوان ژورنال: Synfacts
سال: 2022
ISSN: ['1861-194X', '1861-1958']
DOI: https://doi.org/10.1055/s-0042-1753104