Synthesis of Biologically Active Peptides using Newly Designed N-Vinyl Pyrrolidone Incorporated Flexible Cross linked Polystyrene

نویسندگان

چکیده

Synthesis of NS1 and NS2 peptide fragment hepatitis C virus polyprotein was carried out on a terpolymer- polystyrene, N-vinylpyrrolidone, 1,6-hexanediol diacrylate resin (PS-NVP-HDDA). The radical aqueous suspension polymerisation resulted in the resin, that exhibited high swelling capacity various solvents. peptides were synthesized step-wise by Fmoc strategy, established with amino acid analysis purified using HPLC. polymer's degree might facilitate free reagent interaction resin-bound functional sites, resulting an increased rate amide bond production. yield purity obtained from new support when compared to Merrifield resin. These synthesis depicts application PS-NVP-HDDA developed for long chain homogeneity yield.

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ژورنال

عنوان ژورنال: Oriental journal of chemistry

سال: 2022

ISSN: ['0970-020X', '2231-5039']

DOI: https://doi.org/10.13005/ojc/380517