Synthesis of 9-Oxo-9,13b-dihydro-7H-benzo[3,4]azepino[2,1-a]isoindole-6-carboxylic Acid Derivatives from Baylis—Hillman Adducts.
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منابع مشابه
Stereoselective synthesis of 1-amino-5-butyl-3-oxo- cyclohexane-1-carboxylic acid derivatives
* corresponding author. e-mail: [email protected] Butyl-substituted 1-amino-3-oxocyclohexane-1-carboxylic acid derivatives have been prepared from 5,5-tethered dienes of (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine in stereoselective synthesis. RCM reactions of the diene afforded a heterospirenone which was the substrate for the conjugated addition reaction with lithium dibutylcuprate. Hydrol...
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4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by (1)H-NMR, (13)C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
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The title racemate, C(11)H(14)O(3), aggregates in the crystal structure as acid-to-ketone O-H⋯O hydrogen-bonding catemers whose components are glide-related. The relative stereochemistry at the carboxyl group arises spontaneously during the synthesis. Two inter-molecular C-H⋯O=C close contacts were found, both involving the acid group.
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4,5-Dihydro-7H-pyrano[3,4-c]isoxazoles (II and III) with an o-chlorophenyl or p-chlorophenyl group at C-7 were synthesized and the effect of substitution at C-3 of II and III on fungicidal activity was investigated in vivo. When the substituent at C-3 of II and III was CH2Br, CH=NOMe, CH=NOEt or CH=NO-allyl, the fungicidal effect was significant and selectively high on wheat leaf rust and barle...
متن کاملReductions of Carboxylic Acid Derivatives
Reductions of carboxylic acid derivatives might be expected to lead either to aldehydes or alcohols, functional groups having a lower oxidation state of the carboxyl carbon. that carboxylic acids themselves are reduced to alcohols by lithium aluminum hydride. At this point it will be useful to consider three kinds of reductions: (i) catalytic hydrogenation (ii) complex metal hydride reductions ...
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ژورنال
عنوان ژورنال: ChemInform
سال: 2005
ISSN: 0931-7597,1522-2667
DOI: 10.1002/chin.200549153