Synthesis of 4-L-Leucine-6-O-acetyl-L-serine, 4-L-Leucine, 6-O-Acetyl-L-serine Bradykinin, and Bradykinin
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منابع مشابه
Methyl 2,3-di-O-acetyl-4-O-levulinoyl-1-O-(2,2,2-trichloro-2-iminoethyl)-l-idopyranosiduronate
In the title compound, C(18)H(22)Cl(3)NO(11), a novel derivative of l-idopyran-osiduronic acid, the six-membered ring adopts a chair conformation.
متن کاملSynthesis and pharmacological activity of O-(5-isoxazolyl)-L-serine.
A novel isoxazole derivative, O-(5-isoxazolyl)-L-serine (OIS, 1), was synthesized by a Mitsunobu reaction of isoxazolin-5-one (4) with N-Boc-L-serine tert-butyl ester (5) and subsequent deprotection of the coupling product. Its structure was elucidated by spectroscopic analyses. The pharmacological activity of 1 was also examined with cloned glutamate receptors and transporters using a Xenopus ...
متن کاملThe control of sulphate reduction in Escherichia coli by O-acetyl-L-serine.
1. Extracts of Escherichia coli A.T.C.C. 9723 and K(12)703 contain serine transacetylase and O-acetylserine sulphhydrase. Synthesis of the latter enzyme is repressed by growth on l-cyst(e)ine and other sulphur compounds. 2. O-Acetyl-l-serine added to cells growing on glutathione or sulphate as source of sulphur induces the enzymes that catalyse (a) the activation of sulphate to adenosine 3'-pho...
متن کاملThe enzymatic exchange of L-serine with O-phospho-L-serine catalyzed by a specific phosphatase.
Materials and Methods-nn-Serine-3-C14 was purchased from the Volk Radiochemical Company. n-Serine-3-V and n-serine3-V were generous gifts of Dr. Manfred Karnovsky. Orthophosphate labeled with Ps2 was obtained from the Atomic Energy Commission. ATP labeled in the two terminal phosphates with Ps2 was prepared by a method similar to that of Lowenstein (3). Pi was determined by a procedure based on...
متن کاملActive transport of O-diazoacetyl-L-serine and 6-diazo-5-oxo-L-norleucine in Ehrlich ascites carcinoma.
The amino acid analog O-diazoacetyl-L-serine (azaserine) (1) inhibits the growth of a number of microorganisms (8), the chick (7) and rat (17) embryo, and a number of animal tumors (10, 22, 23). Its activity against the latter has led to a clin ical trial (9). In bacterial systems its effects are partly prevented by some of the aromatic amino acids, as well as phenylpyruvate, tyramine, ßphenyl...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1966
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.14.217