Synthesis of 2, 6-Disubstituted 5-Aminopyrimidin-4-ones from 2, 6-Disubstituted 5-Acetylpyrimidin-4-one Oximes through Beckmann Rearrangement
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چکیده
منابع مشابه
Reaction of 2 , 5 - Disubstituted - l , 3 , 4 - oxadiazoles
Some 5-aryl-2-mercapto-1,3,4-oxadiazole (I) reacted with maleic anhydride, maleic acid and p-benzoquinone affording 2-(5-aryl-1,3,4-oxadiazol-2-ylthio)succinic anhydrides (II), 2-(5-aryl-1,3,4-oxadiazol-2-ylthio)succinic acids (III) and 2-(2,5-dihydroxyphenylthio)-5-aryl-l,3,4-oxadiazoles (IV), respectively. Treatment of 2-methylthio-5-phenyl-l,3-oxadiazole (V) with amines gives 2-[(alkyl or ar...
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Article history: Received on: 07/02/2017 Accepted on: 21/03/2017 Available online: 30/07/2017 The current therapy of epilepsy is associated with a number of side effects including sedation and hypnosis. Newer improved molecules are needed with lesser side effects and with improved physical properties. In view of these facts, a series of novel 4, 5-disubstituted-1,2,4-triazoles (6a-o) were synth...
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This study describes the organic synthesis of 5-(2-amimo-4-styryl pyrimidine-4-yl)-4-methoxy benzofuran-6-ol (SPBF) as an example of a benzofuran derivative used as a new series of amyloid imaging agents. These benzofuran derivatives may be useful amyloid imaging agents for detecting B-amyloid plagues in the brain of Alzheimer’s disease. The precursor is 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-p...
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The title compound, C(20)H(32)N(2)OS, was obtained during the course of our investigation on 2-alkylsulfanyl-6-benzyl-3,4-dihydropyrimidin-4(3H)-ones (S-DABOs) showing favourable anti-HIV-1 activity. Both cyclo-hexane rings adopt chair conformations. The angle at the methyl-ene C atom linking the pyrimidine and cyclo-hexane ring is 113.7 (3)°, which is in the range considered optimal for maximu...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1995
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.115.3_256