SYNTHESIS OF 19-NORTESTOSTERONE ACETATE-4-C14 AND 17β-ESTRADIOL-4-C14

Metabolism of Coprostanol-c14 and Cholestanol-4-c14 in Man.

Absorption and metabolism of cortisone-4-C14 acetate.

Previous work in this laboratory with steroids labeled with Cl4 (l-10) has been extended to include the present experiments on the absorption and disposition of the radioactive carbon of cortisone-4-U4 acetate’ in the rat. Since the conditions of these experiments, i.e. solvent vehicle, strain and type of animal studied, operative techniques, method of collection of specimens, and Cl4 assay, di...

The incorporation of formate-C14, glycine-2-C14, adenine-4, 6-C14, and phosphate-P32 into nucleic acids.

nine labeled either with C'4 or N'5. Considerable controversy has developed as to which one of these tracer compounds gives an accurate measurement of the “relativeturnover-rate― of the nucleic acids. In order to determine the “absolute turnover rate― of the nucleic acids, it is necessary to know the specific activity of the immediate precursor of the nucleic acids. Since even the ident...

Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14.

It has become increasingly apparent in recent years that certain structural alterations of corticosteroids cause an increased biological potency of the resultant steroid (2). A number of chemical and microbiological alteration products of hydrocortisone exhibit enhanced anti-inflammatory potency coupled with unchanged or depressed mineralocorticoid activity (2, 3). As a result, steroids bearing...

The conversion of testosterone-3-C14 to C14-estradiol-17beta by human ovarian tissue.

There is a considerable body of biological data linking testosterone and other 19-carbon steroids with the estrogens. Both ovaries and testes may, under certain circumstances, produce androgens and estrogens (14). The administration of testosterone and other androgens to human subjects leads to an increased urinary excretion of estrogenic material (5-lo), which has been identified as estrone, e...