Synthesis of 1,5-Disubstituted Tetrazoles in Aqueous Micelles at Room Temperature

The ongoing study is a Ugi-azide four-component reaction for the synthesis of 1,5-disubstituted tetrazole(1,5-DST), which involves an aldehyde, different amines, isocyanides, and as azide’s source Trimethylsilylazide (TMSN3), in water solvent using catalyst tetradecyltrimethylammonium bromide (TTAB) with load (10% mole), provides hydrophobic micellar site. This approach step toward green chemistry 1,5 disubstituted tetrazole. A serie 1, 5- tetrazole was synthesized by engaging large substrate scope, leading to yields between 43% 56%, are compared afterwards those obtained methanol solvent. results were confirmed HRMS, IR, 1D NMR experiments.