Synthesis, characterization, anticancer, and antioxidant activities of chitosan Schiff bases bearing quinolinone or pyranoquinolinone and their silver nanoparticles derivatives

Abstract In this work, new chitosan-based Schiff bases were synthesized by the reaction of chitosan with quinolinone and pyranoquinolinone giving CSQ , CSP respectively. The novel Chitosan grafted on silver nanoparticles providing CSQ/Ag CSP/Ag structures. Characterization isolated compounds was carried out FT-IR, TGA, XRD, SEM, TEM. target evaluated as antitumor agents against three cancer cell lines, liver (HepG-2), colon (HCT-116), breast (MCF-7). Compound disclosed potent cytotoxic effect IC 50 values in range 41.9–55.1 ?g/ml comparison 5-fluorouracil different lines. Besides, antioxidant activity its analogues assessed radical scavengers versus 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH%). compound emerged most active member scavenging DPPH radicals. obtained findings proved that bases/silver showed higher antiproliferative activities than blank CS would be highly applicable biomedical fields. Graphical abstract