Synthesis, Characterization, and Antimicrobial Activity of New 1,2,3-Thiadiazole and 1,2,3-Selenadiazole Derivatives

1,2,3-Thiadiazole, 1,2,3-selenadiazole, and semicarbazones that are prepared from ketones promising moieties for lead compound development. New 1,2,3-thiadiazole (2c-4c) 1,2,3-selenadiazole derivatives (2d–4d) were the corresponding (2b-4b). The (2b-4b) (2a-4a). Characterization of synthesized compounds was performed using infrared spectra (IR), proton nuclear magnetic resonance (1H-NMR) spectra, carbon (13C-NMR), ultraviolet mass spectrometry, elemental analysis. antimicrobial activity explored in vitro against various pathogenic microbes. All heterocyclic had positive activity, but these activities varied extent coverage. Compounds (2c) (2d) Staphylococcus aureus Escherichia coli without any antipseudomonal activity. Compound (3c) most Candida albicans with potential as a novel antifungal agent along some Gram-positive Gram-negative bacteria. (4c) (4d) exhibited broad-spectrum coverage which both demonstrated all microorganisms explored. Interestingly, they substantial local resistant Pseudomonas aeruginosa reference P. (ATCC 27853). This may suggest antibacterial agents In conclusion, new (2d-4d) identified agents.