Synthesis and utilization of siderophores by Shigella flexneri

Shigella flexneri inhibition by acetic acid.

The degree of Shigella flexneri inhibition by acetic acid in a chemically defined medium was dependent upon the concentration of undissociated acetic acid in the medium. Under the conditions of the experiments, the critical concentration of undissociated acetic acid that completely inhibited S. flexneri multiplication was approximately 0.0018 M. Adjustment of the medium from pH 6.0 to 7.0 after...

Phage-dependent changes in Shigella flexneri type antigen synthesis.

Lysogenic conversion of Shigella flexneri type antigens was studied with the aid of wild-type and thermosensitive mutant phages. With all wild-type phages, the appearance of glycosylated antigen was accompanied by the appearance of polyprenyl phosphate glucose synthetase activity. With some of the mutant phages, the appearance of glycosylated antigen was not followed by the formation of lipid-l...

Splenic abscess caused by Shigella flexneri and Bacteroides fragilis.

We report a case of splenic abscess from which only Shigella flexneri (serotype 1a) and Bacteroides fragilis were isolated. The patient was a 59-year-old diabetic female who displayed minimal gastrointestinal symptoms. The S. flexneri isolate was resistant to chloramphenicol and tetracycline. The possible synergistic relationship between the two organisms is discussed.

Keratitis due to Shigella flexneri.

Multiresistant Shigella flexneri isolates were cultured from the cornea and stool of a girl. Genetic analysis showed the isolates were identical. Shigella spp. are rare causes of ulcerative keratitis; there have only been 14 published cases since 1943. Although prognosis after local treatment is good, shigellosis is a systemic infection, possibly leading to dehydration.

Fulminating encephalopathy and Shigella flexneri infection.