Synthesis and structural determination of pyrrolidine-2,3-dione derivatives from 4-acetyl-3-hydroxy-5-phenyl-1-(3-nitrophenyl)-3-pyrroline-2-one
نویسندگان
چکیده
Numerous heterocyclic compounds containing 3-pyrroline-2-one or pyrrolidine-2,3-dione core have been found in nature and showed valuable biological activities. Therefore, the synthesis of derivatives attracted more attention from organic chemists medicinal chemists. In this manuscript, 4-acetyl-3-hydroxy-1-(3-nitrophenyl)-5-phenyl-3-pyrroline-2-one has prepared via three-component reaction and, besides, two 1,4,5-trisubstituted pyrrolidine-2,3-diones also synthesized between above derivative aliphatic amine such as methylamine and4-methoxybenzylamine. The structure desired products confirmed 1D NMR (1H NMR, 13C NMR), 2D (HSQC, HMBC) high resolution mass spectrometry (ESI – HRMS).
منابع مشابه
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ژورنال
عنوان ژورنال: The University of Danang - Journal of Science and Technology
سال: 2023
ISSN: ['1859-1531']
DOI: https://doi.org/10.31130/ud-jst.2023.519e