Synthesis and evaluation of novel pyrazole-imidazole hybrids as antimicrobial candidates

The present study describes a facile and efficient synthesis of 1-(N-arylacetamide)-4-phenyl-2-pyrazolyl-imidazole 7a–7t by reacting 1-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole (3a)/3,5-dimethyl-1-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole (3b) with 2-bromo-N-substitutedacetamide 6a–6j) in good yield. structure compounds are confirmed various spectral techniques. All the prepared examined for in-vitro antimicrobial activities against three bacterial strains; S. aureus, B. subtilis E. coli two fungal C. albicans A. niger. synthesized analogues show moderate inhibitory activity tested strains 7a, 7b, 7l, 7m 7r exhibited albicans. Most obey Lipinski rule five. compound 7b is docked active site sterol-14α-demethylase DNA gyrase to find binding conformation.