?Synthesis and evaluation of inhibitory potentials of microbial biofilms and quorum-sensing by 3-(1,3-dithian-2-ylidene) pentane-2,4-dione and ethyl-2-cyano-2-(1,3-dithian-2-ylidene) acetate

The virulence and resistance of pathogenic microorganisms are promoted by quorum-sensing (QS) mediated traits biofilms. development antimicrobial agents which can reduce the incidence microbial disrupting establishment biofilms QS, constitute a suitable strategy to emergence strains that resistant antibiotics. In this study, 3-(1,3-dithian-2-ylidene) pentane-2,4-dione ( 1 ) ethyl-2-cyano-2-(1,3-dithian-2-ylidene) acetate 2 were successfully synthesized characterized using EIMS, H NMR 13 C techniques. On S. aureus , both compounds had MIC (minimal inhibitory concentrations) 0.625 mg/mL while on E. coli C. albicans compound showed higher activity than 1. All inhibited formation at sub-MIC with being more active 2. only biofilm formation. Violacein production violacein in violaceum CV12472 quorum sensing CV026 indicating could block signal reception. Anti-quorum concentrations revealed inhibition zones 13.0±0.5 mm 8.0±0.5 MIC/2 respectively for 2, they 11.5±0.4 7.5±0.0 respectively. Concentration-dependent swarming motility was exhibited slightly results indicate organosulphur be candidates modern