Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes
نویسندگان
چکیده
منابع مشابه
Synthesis and evaluation of a novel lipophilic folate receptor targeting ligand.
BACKGROUND Folate receptor (FR)-targeted liposomes have been investigated as delivery vehicles for anticancer drugs. A novel lipophilic FR ligand, folate-glutathione-polyethyleneglycol-distearoyl phosphatidylethanolamine (F-GSH-PEG-DSPE), was synthesized, incorporated into liposomes and evaluated for FR targeting efficiency. These liposomes were then evaluated as carriers of the chemotherapy ag...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2008
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2007.12.030