Synthesis and Characterization of Dimeric Thio-Schiff Bases by Nano Cerium Oxide and Examination of Their Antimicrobial Activities

In this work, firstly, CeO2 nanoparticles, which can be used as catalysts in many reactions, were synthesized by preparing aqueous solution of cerium(III) nitrate hexahydrate basic medium. the second step, synthesis dimeric thio Schiff bases was carried out using two different methods. Effect catalyst on some parameters such reaction time and yield product investigated. The antimicrobial activities ligands have been screened vitro against organisms Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae (Gram negative bacteria), Staphylococcus aureus, epidermidis, Enterococcus faecalis, Bacillus cereus positive bacteria) Candida albicans, C. tropicalis, guilliermondii, glabrata Disc Diffusion Microdilution At same time, compared to standard antibiotics (Cefotaxime, Amoxicillin/clavulanic acid, Posacanazole, Nystatin Gentamicin). Generally, results obtained research showed that all tested exhibited more effect towards Gram bacteria species antibiotics.