Synthesis and biological evaluation of selective tubulin inhibitors as anti-trypanosomal agents
نویسندگان
چکیده
منابع مشابه
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
The potency of a series of sulfonamide tubulin inhibitors against the growth of Trypanosoma brucei (T. brucei), as well as human cancer and primary fibroblast cells were evaluated with the aim of determining whether compounds that selectively inhibit parasite proliferation could be identified. Several compounds showed excellent selectivity against T. brucei growth, and have the potential to be ...
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OBJECTIVES There is an urgent need to develop a safe, effective, orally active, and inexpensive therapy for African trypanosomiasis due to the drawbacks of current drugs. Selective tubulin inhibitors have the potential to be promising drug candidates for the treatment of this disease, which is based on the tubulin protein structural difference between mammalian and trypanosome cells. We propose...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2017
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2017.04.009