Synthesis and Biological Evaluation of New Chromenes and Chromeno[2,3-d] pyrimidines

ABSTRACT A simple and efficient approach has been developed to synthesise novel functionalised 5H-chromeno[2,3-d] pyrimidines derivatives (4a-h). This entails treating 2-amino-3-cyano-4H-chromenes (3a-h) with formamidine acetate under microwave irradiations solvent-free conditions. All structures of new compounds obtained in this study were characterised by IR, MS, 1H 13C NMR analysis. Additionally, the synthesised investigated for their antibacterial antioxidant potential. Compounds 3b, 3c, 3e, 4c 4e showed significant activities. Keywords: pyrimidine; 4H-chromene; conditions; activity; activity