SYNTHESIS AND ANTIMICROBIAL SCREENING OF 2,6-DIAMINOPYRIDINE SCHIFF BASES OF ISATIN DERIVATIVES

Objective: Synthesis and in vitro antimicrobial screening of 2,6-diaminopyridine Schiff bases isatin derivatives.
 Methods: Isatin it’s 5-substituted derivatives (S1-5) were prepared by Sandmeyer method N2-Benzylidenepyridine-2,6-Diamine (M) was obtained the reacting with benzaldehyde. (MS1-5) (M). Resultant compound structures confirmed some analytical techniques’ data. All synthesized screened for activity broth dilution methods against Staphylococcus aureus (MTCC-3160), Bacillus subtilus (MTCC-441), Escherichia coli (MTCC-452), Klebsiella pneumoniae (MTCC-432), Candida albicans (MTCC-183), Aspergillus flavus (MTCC-277) using ciprofloxacin fluconazole as standard drugs.
 Results: compounds exhibited better antibacterial compared to standard. Among all compounds, MS2 MS4 found most effective strains bacteria. Only MS3 MS5 showed antifungal both fungal strains.
 Conclusion: newly significant tested strain bacteria, only a few antifungal.