Synthesis and anticancer properties of 5-(1H-benzoimidazol-2-ylmethylene)-4-oxo-2-thioxothiazolidin-3-ylcarboxilic acids
نویسندگان
چکیده
The reaction of 1 H -benzoimidazole-2-carbaldehyde with 4-oxo-2-thioxothiazolidin-3-ylcarboxilic acids was studied and the combinatorial library 5-(1 -benzoimidazol-2-ylmethylene)-4-oxo-2-thioxothiazolidin-3-ylcarboxilic has been prepared. structures target compounds 8a-f , 9 10a, b were confirmed by using NMR spectroscopy elemental analysis. synthesized selected National Cancer Institute (NCI) Developmental Therapeutic Program for in vitro cell line screening to investigate their anticancer activity. tested displayed a weak medium most sensitive lines turned out be SNB-75 CNS (GP = 74.84–85.73%) UO-31, Renal cancer 71.53–82.16%) compound 10a K-562 Leukemia 57.14). Graphical abstract
منابع مشابه
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ژورنال
عنوان ژورنال: ????????
سال: 2021
ISSN: ['2411-6076', '2709-135X']
DOI: https://doi.org/10.3897/pharmacia.68.e49224