Synthesis and antibacterial activity of racemic paecilocin A and its derivatives against methicillin-sensitive and -resistant Staphylococcus aureus
نویسندگان
چکیده
A total synthesis in four steps of racemic paecilocin A, a natural marine phthalide is reported. The synthetic pathway includes an iodine-magnesium exchange followed by condensation on aldehyde and represents sufficiently flexible approach to allow the twelve analogs. synthesized compounds were investigated for their antibacterial activity against methicillin-sensitive Staphylococcus aureus (MSSA) methicillin-resistant strain (MRSA). Three analogs found have similar or better than compound MRSA.
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2021
ISSN: ['0040-4039', '1873-3581']
DOI: https://doi.org/10.1016/j.tetlet.2021.152888