Synthesis and Anti-Inflammatory Activity of Pyrazolines
نویسندگان
چکیده
منابع مشابه
Antitumor, Analgesic, and Anti-inflammatory Activities of Synthesized Pyrazolines
Nitrogen heterocyclic compounds such as pyrazolines have been found to possess a broad spectrum of biological activities such as anticancer, antitubercular, anti-inflammatory, analgesic, and antidepressant activities. Pyrazoline derivatives IV, V (a-e) have been synthesized from the intermediate chalcones III (a-h) by cyclizing with phenyl hydrazine and hydrazine hydrate. The structures of thes...
متن کاملSynthesis of some chalcones and pyrazolines carrying morpholinophenyl moiety as potential anti-inflammatory agents.
Chalcones of 2a-f and their corresponding products, pyrazolines 3a-f, were synthesized and evaluated for their anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. The most active compounds of this series, 2a, 2b, and 2d, were found to be most potent. They showed higher percentage...
متن کاملAnti-Nociceptive and Anti-Inflammatory Activity of Araucaria bidwillii Hook
The effect of alcoholic extracts of leaf from Araucaria bidwillii Hook. [ABH] (Family: Araucariaceae) was evaluated in experimental models of pain and inflammation. Oral administration of 100, 200 and 300 mg/kg of leaf extracts of ABH were used for the above study. The leaf extract at 300 and 200 mg/kg showed significant reduction in acetic acid induced writhings in mice with a maximum effect o...
متن کاملNovel Pyrazolines: Synthesis and Evaluation of Their Derivatives with Anticancer and Anti-inflammatory Activities
Objective: Synthesis of novel pyrazolines (P2-P4 & P7-P9) from the chalcones (C2-C10) obtained by condensing different aldehydes with 2-acetyl5-bromothiophene and evaluates them for in vitro anticancer and anti-inflammatory activities. Methods: The synthesized pyrazolines and chalcones were screened for anticancer activity against human breast cancer cell lines-MCF-7 and MDAMB-468 in the range ...
متن کاملSynthesis, Characterization and Anti-Inflammatory Activity of Some 1, 3,4 -Oxadiazole Derivatives
A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1-C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified...
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ژورنال
عنوان ژورنال: E-Journal of Chemistry
سال: 2010
ISSN: 0973-4945,2090-9810
DOI: 10.1155/2010/731675