منابع مشابه
Bio012252 993..1001
The expression level of inhibitor of DNA binding 2 (Id2) is increased in colorectal carcinomas and is positively correlated with poor prognosis. However, the functional significance of Id2 in intestinal tumorigenesis has not been fully defined using genetic approaches. Here, we show that Id2 promotes ileal tumor initiation in Apc-deficient mice. Expression of Id2 was stimulated by Wnt signaling...
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The largest gene knock-down experiments performed to date have used multiple short interfering/short hairpin (si/sh)RNAs per gene1–3. To overcome this burden for design of a genomewide siRNA library, we used the Stuttgart Neural Net Simulator to train algorithms on a data set of 2,182 randomly selected siRNAs targeted to 34 mRNA species, assayed through a high-throughput fluorescent reporter ge...
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Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N-demethylation to 2-ethyl-1,5-dimethyl3,3-diphenylpyrrolidine (EDDP). Retrospective studies suggest that individuals with the CYP2B6*6 allelic variant have higher methadone plasma concentratio...
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Imagine trying to count grains of rice in a cup that are shaking about, and then assume the grains are less than a nanometer long. This is akin to what David Hume and colleagues from the University of Heidelberg in Germany have recently done [1]. As reported in Physical Review Letters, by observing the light emitted from a collection of laser-cooled and trapped atoms, they can distinguish two e...
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distance, in noninfected organs. infected B cells influence T cells located at draining the site of inoculation, and the Murine AIDS is initiated in the lymph nodes
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ژورنال
عنوان ژورنال: Synthesis
سال: 2004
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-2001-16094