Syntheses of Two 5-Hydroxymethyl-2′-deoxycytidine Phosphoramidites with TBDMS as the 5-Hydroxymethyl Protecting Group and Their Incorporation into DNA
نویسندگان
چکیده
منابع مشابه
Synthesis of 5-acetoxymethyl- and 5-hydroxymethyl-2-vinyl-furan.
5-Acetoxymethyl- and 5-hydroxymethyl-2-vinylfuran were synthesized by two routes. The first route starts from 2-methylfuran and the second from furfuryl acetate. The latter route, involving successive Vilsmeier-Haack and Wittig reactions, is suitable for producing 5-acetoxymethyl-2-vinylfuran and 5-hydroxymethyl-2 vinylfuran in 68% and 60%yields, respectively.
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Population growth has created an expanding gap between the supply and demand of both energy and chemicals. Nonrenewable fossil sources, such as coal, natural gas, and petroleum, are the source of nearly 86% of the world’s energy and 96% of its organic chemicals. Diminishing reserves of these sources, rising atmospheric CO2 levels, and socioeconomic concerns require a reduction of our dependence...
متن کاملIdentification and Quantification of 5-Hydroxymethyl Furfural in Food Products
5-Hydroxymethylfurfural (5-HMF) is known as an indicator of quality deterioration in a wide range of foods. The current study covered 70 samples taken from domestically produced foods and drinks available on the Iranian markets (including honey, jam, fruit cakes tomato paste, ketchup, syrup, fruit juice, canned fruit, UHT milk, instant coffee and jelly powder). HMF levels were determined using ...
متن کامل(5-n-Hexyl-2-hydroxymethyl-1,3-dioxan-2-yl)methanol
In the title compound, C(12)H(24)O(4), the dioxane ring adopts a chair conformation; the n-hexyl chain, which occupies an equatorial position, has an extended zigzag conformation. In the crystal, mol-ecules are connected by O-H⋯O hydrogen-bonds into a zigzag chain running along the b axis, giving rise to a herringbone pattern.
متن کاملMutagenicity of 5-hydroxymethyl-2'-deoxyuridine to Chinese hamster cells.
5-Hydroxymethyluracil (HmUra) is formed from thymine in DNA through the action of ionizing radiation or reactive oxygen species generated by activated leukocytes. HmUra is removed from DNA by a specific DNA glycosylase, suggesting that it is also formed from endogenously generated reactive oxygen species and that its formation in DNA is potentially deleterious. To determine whether HmUra residu...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2011
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo200566d