Syntheses of ornithine decarboxylase inhibitors: D- and DL-.ALPHA.-hydrazinoornithine.
نویسندگان
چکیده
منابع مشابه
Screening of microbial inhibitors of mammalian ornithine decarboxylase.
Sir: In the course of searching for inhibitors of mammalian ornithine decarboxylase (ODC), an active compound was isolated from the culture broth of an unidentified fungus and identified as citrinin, a known antibiotic1,2). Citrinin showed cytotoxicity in vitro to mouse leukemia cells. Structurally related compounds were examined for possible inhibition of ODC and cytotoxicity, and we found tha...
متن کاملRegulation of mammalian ornithine decarboxylase.
17 Melvin, M. A. L. and Keir, H. M. (1978) Expt. Cell Res. 111,231-236 18 Melvin, M. A. L. and Keir, H. M. (1979) Biochem. SOC. Trans. 7, 689-691 19 Wallace, H. M. and Keir, H. M. (1981) Biochim. Biophys. Acta 676,25-30 20 Melvin, M. A. L., Wallace, H. M. and Keir, H. M. (1980) Physiol. Chem. Phys. 12, 431-439 21 Coleman, C. S. and Wallace, H. M. (1990) 'Biochem. SOC. Trans. 18, 1228-1229 22 Wa...
متن کاملRegulation of Adrenal Ornithine Decarboxylase
were not secondary to stimulation of steroidogenesis, since hydrocortisone had no effect on adrenal ornithine decarboxylase although it did stimulate activity of the enzyme in the liver and kidney. ACTH, given subcutaneously to hypophysectomized rats, induced striking increases in adrenal cyclic AMP levels within 15-30 min with a fall towards the base line in 1 h. Increases in ornithine decarbo...
متن کاملThe Functions and Regulation of Ornithine Decarboxylase
..............................................................................................................4 LIST OF ORIGINAL PUBLICATIONS...................................................................7 ABBREVIATIONS ...................................................................................................8 INTRODUCTION...............................................................
متن کاملPurification and Properties of Ornithine Decarboxylase
Inducible ornithine decarboxylase from Lactobacillus sp. 30a has been purified to homogeneity as judged by ultracentrifugation and gel electrophoresis. Unlike histidine decarboxylase from the same species (a pyruvoyl enzyme), ornithine decarboxylase is a pyridoxal phosphate enzyme. The purified enzyme is specific for Lornithine (Km 1.7 m ~ ; specific activity, 150 to 200 pmol min” mg” at 37°C) ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1976
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.24.326