Syntheses of <i>dl</i>-4, 4&prime;-Bis(2-methyl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydro-1-isoquinolylmethyl)-biphenyl and <i>dl</i>-5, 5&prime;-Bis(2-methyl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydro-1-isoquinolylmethyl)-2, 2&prime;-dimethoxybiphenyl

1 , 4 - Phenylenebis [ ( 6 , 7 - dimethoxy - 3 , 4 - dihydroisoquinolin - 2 ( 1 H ) - yl ) methanone ]

The compound named in the title was prepared from N1,N4-diphenethylterephthalamide 1. The resulting bis terephthalamide was subjected to an intramolecular α-amidoalkylation reaction with paraformaldehyde in the presence of heterogeneous catalyst TfOH/SiO2 to obtain 1,4-phenylenebis[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone]. The structure of the newly synthesized compound was det...

2-Amino-4-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile

In the title compound, C(10)H(12)N(2)S, the thio-phene ring is essentially planar (r.m.s. deviation = 0.0290 Å). The two C atoms of the cyclo-hexene ring (at positions 6 and 7) are disordered over two sets of sites in a 0.810 (5):0.190 (5) ratio. The cyclo-hexene rings in both the major and minor occupancy conformers adopt a half-chair conformation. In the crystal, there are two types of N-H⋯N ...

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1 1 2 3 4 5 6 Complex craniofacial changes in blind cave-dwelling fish are mediated by genetically symmetric 7 and asymmetric loci 8 9 Joshua B. Gross, Amanda J. Krutzler and Brian M. Carlson 10 11 Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 12 13 14 15 16 17 18 19 20 21 22 23 Genetics: Early Online, published on February 4, 2014 as 10.1534/genetics.114.1...

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A decentralized failure detection and isolation (FDI) methodology, which is robust with respect to model uncertainties and noise, is presented. Redundancy metrics are developed, and optimization problems are posed for the choices of robust parity relations. Closed-form solutions for some special failure cases are given. Connections are drawn with other disciplines, and the use of the metrics to...