Syntheses of Biguanide Derivatives containing Diphenyl Ether and Diphenyl Sulfide Nucleus
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چکیده
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Synthesis and antitubercular activity of heterocycle substituted diphenyl ether derivatives.
Despite being an ancient disease, tuberculosis (TB) remains the leading single-agent infectious disease killer in the world. The emerging serious problem of TB control and clinical management prompted us to synthesize a novel series of heterocyclic substituted diphenyl ether derivatives and determine their activity against the H37Rv strain of Mycobacterium. All ten compounds inhibited the growt...
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A series of triclosan mimic diphenyl ether derivatives have been synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The binding mode of the compounds at the active site of enoyl-acyl carrier protein reductase of M. tuberculosis has been explored. Among them, compound 10b was found to possess antitubercular activity (minimum inhibitory ...
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We adapted an indoor multimedia fugacity model to consider emissions and fate of polybrominated diphenyl ethers (PBDEs) and to understand the variability of indoor concentrations. The model was applied to an office in which an 80% decrease in PBDE air concentration was observed after an old computer was exchanged with a newer one. PBDE-impregnated polyurethane foam (PUF) and carpet were treated...
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Two cyclic oligoureas with 64- and 80-membered rings in which two sets of three or four rigid xanthene (X) units are connected via flexible diphenyl ether (D) units were synthesized by a stepwise fragment condensation. The compounds were characterized by (1)H NMR and ESI mass spectrometry. The structure of the cyclic octamer (XXXDXXXD) was additionally confirmed by single crystal X-ray analysis...
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The effects of the diphenyl ether herbicides HOE 29152 (methyl-2[4-(4-trifluoromethoxy) phenoxy] propanoate) and nitrofluorfen (2-chloro-1-[4-nitrophenoxy]-4-[trifluoromethyl]benzene) on photosynthetic electron transport have been examined with pea seedling and spinach chloroplasts. Linear electron transport (water to ferricyanide or methylviologen) is inhibited in treated chloroplasts, but nei...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1959
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.79.3_386