منابع مشابه
Opioid Analgesics
Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...
متن کاملTopical analgesics.
BACKGROUND AND OBJECTIVES Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically or into the neuraxis. However, when analgesics are applied through these pathways, they are associated with significant side effects, which can hinder its use. Topical administ...
متن کاملPharmacogenetics of new analgesics.
Patient phenotypes in pharmacological pain treatment varies between individuals, which could be partly assigned to their genotypes regarding the targets of classical analgesics (OPRM1, PTGS2) or associated signalling pathways (KCNJ6). Translational and genetic research have identified new targets, for which new analgesics are being developed. This addresses voltage-gated sodium, calcium and pot...
متن کاملNITROIMIDAZOLES XI [I]. SYNTHESES OF DISUBSTITUTED NITROIMIDAZOLYLQUINOLINES
Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methy...
متن کاملSYNTHESIS AND PHARMACOLOGICAL EVALUATION OF N-METHYL PIPERIDINE ANALGESICS
Pain is probably the immediate stimulus for more visits to the Physician's office than all other complaints combined. Since pain serves as an alert to injury, it is often the first harbinger of disease. Piperidine has been extensively utilized for the synthesis of a wide range of therapeutic agents in general and analgetics in particular for the mitigation of pain. In a similar attempt, th...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1954
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.74.11_1141