Synergy between Pyrvinium Pamoate and Azoles against Exophiala dermatitidis
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چکیده
منابع مشابه
INK128 Exhibits Synergy with Azoles against Exophiala spp. and Fusarium spp.
Infections of Exophiala spp. and Fusarium spp. are often chronic and recalcitrant. Systemic disseminations, which mostly occur in immunocompromised patients, are often refractory to available antifungal therapies. The conserved target of rapamycin (TOR) orchestrates cell growth and proliferation in response to nutrients and growth factors, which are important for pathogenicity and virulence. IN...
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No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% growth inhibition in human enterocytic HCT-8 cells by a quantitative alkaline phos...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2018
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02361-17