Synergistic Antitumor Activity of Gramicidin/Lipophilic Bismuth Nanoparticles (BisBAL NPs) on Human Cervical Tumor Cells

The objective of this study was to the synergistic antitumor effect lipophilic bismuth nanoparticles (BisBAL NPs) with antibiotic solution Neo-Poly gramicidin on human cervical tumor cells. BisBAL NPs and cancer cell line (HeLa) determined by MTT viability assay fluorescence microscopy. After a 24-h exposure 0.1× HeLa growth decreased 94%. Fluorescence microscopy confirmed death higher among treated than non-treated cells Individually, (0.04 mg/mL) inhibited most (40%), neomycin least (21%). Gramicidin (0.3 in combination different concentrations (1–150 μM) had against cells, reaching an < 86% inhibition. As far as we know, are first describe activity line. action mechanism gramicidin/BisBAL NP is based strong damage membrane nucleus A may be useful alternative therapy for patients.