Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugs

The appearance of antifungal resistance promotes the investigation therapeutic options. There are few studies on combined effect drugs and essential oils (EOs). In present work, regarding association eight EOs Andean plants with agents against a panel fungi strains. Combinatorial effects were determined using Fractional Inhibitory Concentration Index (FICI) Dose Reduction (DRI). A combination A. cryptantha-B EO fluconazole showed synergistic C. Albicans (FIC = 0.31 DRI 16.25). from cryptantha-A L. integrifolia an additive (FICI 0.75) neoformans. seriphioides terbinafine T. rubrum 0.56; 16) M. gypseum 1.03; 32). conclusion, combinations between species commercial yielded some interesting findings, as potential strategies used for treating infections associated rubrum.