Synergistic Antibiofilm Effects of Exopolymers Produced by the Marine, Thermotolerant Bacillus licheniformis B3-15 and Their Potential Medical Applications

The exopolysaccharide (EPS B3-15) and biosurfactant (BS B3-15), produced by the marine Bacillus licheniformis B3-15, were recently reported to possess different antibiofilm activities, with EPS being more active in preventing adhesion of Pseudomonas aeruginosa Staphylococcus aureus BS destroying their preformed biofilms on surfaces. In this study, synergistic effects two exopolymers bacterial biofilm disruption P. S. evaluated polystyrene, a medical polyvinyl chloride (PVC) device, contact lenses (CLs) order address potential use biomedical applications. To purpose, B3-15 equally combined (1:1 w/w), mixture (BPS was added at concentrations (from 50 300 µg mL−1) times development. Compared each polymer, BPS (300 efficiently reduced polystyrene (65 58%, respectively), PVC devices (62 42%, CLs (39 35%, also combination care solution (88 39%, respectively). Furthermore, able disrupt mature biofilms, acting effectively against (72%) than (6%). low exhibited prevent eradicate biofilms.